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The search for the relief of pain has existed for centuries if not millennia. It has long been known that the opiates are able to produce excellent analgesia as well as feelings of euphoria. Unfortunately, they are also habit forming, cause respiratory depression, sedation, and hallucinations. As science has examined the brain, several types of opiate receptors have been found such that stimulation of different receptors is responsible for the different effects of the opiates. For example, the “mu” and “delta” receptors account for analgesia (pain relief), euphoria, addiction, reduction in heart rate, and respiratory depression. The “kappa” receptors cause dysphoria (unpleasant feelings), constricted pupils, and sedation. The “sigma” receptors account for hallucinations. In the laboratory, it is possible to create opiates that stimulate only some receptors and not others

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